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Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of CHIP, TRAF6 and TRIM63/MURF1. Ubiquitinates CHIP-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiqui

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene

NgR3 is a 441 amino acid protein that belongs to the Nogo receptor family. Localized to the cell membrane, NgR3 contains 8 LRR (leucine-rich) repeats. NgR3 is predominantly expressed in brain, where it localizes to the surface of neurons, but is also found at lower levels in lung, placenta, kidney, mammary gland, skeletal muscle, spleen and salivary gland. NgR3 is thought to play a role in the regulation of axonal regeneration and plasticity in the adult central nervous system. The gene that

GPRC5B (G protein-coupled receptor family C group 5 member B, retinoic acid-induced gene 2 protein) is a 403 amino acid protein encoded by the human GPRC5B gene. GPRC5B is an orphan receptor member of the G protein-coupled receptor 3 family. G protein-coupled receptors (GPCRs or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. Key roles for G protein-coupled receptors include control of protein maturation and cell surface delivery, ａ